We develop innovative therapeutics aimed at improving the lives of cancer patients. We have built a robust pipeline leveraging our small molecule expertise in targeted protein degradation, immuno-oncology, precision oncology, and epigenetics
AUR-101
RORgt inverse agonist
Stage – Clinical Phase 2B
AUR-101 is an oral, small molecule RORgt inverse agonist. It is the most advanced clinical asset in this class, being developed for the treatment of moderate to severe psoriasis.
Global
Psoriasis, Psoriatic arthritis, Ankylosing spondylitis
CA-170
Dual inhibitor of PDL1 and VISTA#
Stage – Clinical Phase 3
CA-170 is an oral, small molecule dual inhibitor of PDL1 and VISTA. In contrast to antibodies, CA-170 offers the advantages of ease of dosing, the ability to manage immune-related adverse events (irAEs), and lower COGs.
Asia
NSCLC, bladder & kidney cancers
AUR-109
Spectrum selective kinase inhibitor
Stage – Clinical Phase 2A
AUR-109 (formerly known as ODM-203) is an oral, spectrum selective kinase inhibitor targeting DDR1 and SIK2 along with clinically validated targets FGFRs and VEGFRs. It is currently being evaluated in FGFR mutant bladder cancer. The unique selectivity profile allows potential expansion of indications.
Global
Cancers of bladder, lung, breast, ovary, kidney, liver & lung fibrosis
AUR-108
DHODH inhibitor
Stage – Clinical Phase 1
AUR-108 (formerly known as AG-636) is an oral, potent DHODH inhibitor with high selectivity against a panel of dehydrogenases. It has broad activity in pre-clinical models of lymphoma and leukemia, with a potential for combination with standard of care.
Global
Leukaemia and lymphoma
AUR-103
CD47 antagonist*
Stage – Clinical Phase 1
AU-103 is a highly differentiated oral small molecule inhibitor of CD47. In pre-clinical studies, AUR-103 does not show hemotoxicity. This is in contrast to anti-CD47 antibodies, where significant dose-limiting toxicities of anemia, thrombocytopenia, and leukopenia have been observed.
Global
Leukaemia, lymphoma and multiple solid tumors
AUR-105
PRMT5 inhibitor
Stage – Clinical Phase 1
A substrate competitive inhibitor of PRMT5, with a high tumor/plasma ratio in xenograft studies. AU-105 has demonstrated significant efficacy in multiple pre-clinical cancer models.
Global
Leukaemia, lymphoma and multiple solid tumors
AUR-106
Dual inhibitor of TIGIT and PDL1
Stage – Clinical Phase 1
An oral, small molecule inhibitor of TIGIT and PDL1, developed from Aurigene’s small molecule IO platform. In contrast to antibodies, AUR-106 offers the advantages of ease of combination dosing, the ability to manage immune-related adverse events (irAEs), and lower COGs.
Global
Multiple cancers
AUR-107
CBP/p300 inhibitor
Stage – IND-enabling
AUR-107 is an oral, dual inhibitor of CBP and p300 with excellent selectivity against other bromodomain containing proteins. The molecule has demonstrated excellent efficacy in pre-clinical models with good therapeutic margins.
Global
NSCLC, lymphomas, leukemias, bladder cancers and prostate cancers
Selective SMARCA2
Global
SMARCA-4 mutant lung cancers, medulloblastoma; and Burkitt's lymphoma
MALT1 Inhibitor
Global
Lymphoma, R/R NHL, CLL
CDK 12/13 Inhibitor
Global
Breast, Ovarian and Prostate cancers
SMARCA 2/4
dual
Global
Prostate cancer, leukemia, lymphoma and myeloma
CBP/p300 degrader
Global
Breast and prostate cancers
PDL1/A2AR dual
Global
Multiple cancers
CD73-A2AR dual
Global
Multiple cancers
CCR4
Global
Atopic dermatitis and Asthma
* Aurigene will be advancing these programs till marketing approval
# Co-development programs with Aurigene leading clinical trials in India
Here are the key compounds discovered at Aurigene in clinical development.
Novartis
(licensed to Laekna)
CYP17, CFG920
Orion
BET, ODM 207
Astellas
PPARδ modulator, ASP0367
PPARδ modulator, ASP1128
Asana Biosciences
SYK/JAK, ASN002
BRAK/PI3K, ASN003
Japanese Pharma
Not disclosed
H3 Biomedicine
ESR1, H3B-6545
Curis
PD- L1/VISTA, CA170
IRAK4, CA4948
Exelixis
CDK7, XL102